The 2018 Kuo Symposium/Workshop on 3DEM of Cells and Molecules, which will be held at Zhejiang University, Hangzhou, China. Major topics of the Symposium include recent developments in cryoEM sample preparation and data acquisition, advances in cryoEM image analysis and reconstruction, advances in cryoET and in situ structural biology, and correlative and hybrid methods for cellular structural analysis.

The cryoEM meeting and workshop series is named after K.H. Kuo (1923-2006), a prominent Chinese scientist, who is among the pioneers discovered several types of quasicrystals in 1980s. Dr. Kuo was also an important educator and mentor who had fostered a generation of electron microscopists in China, Asia and across the world. Since 2008, the Kuo summer school of electron microscopy has provided numerous opportunities for a new generation of scientists to learn the technique of cryoEM through close interactions with many leading scientists in the field during workshop and symposium.

Workshop and K.H. Kuo Summer School: 24-26 August 2018

2018 Kuo Symposium: 26-29 August 2018

This conference brings together structural biologists from across the pharmaceutical and biotech industry to showcase their cutting-edge research.

Scientific sessions will cover the following topics:
• Cryo-EM
• X-ray crystallography
• Lead discovery using NMR
• Protein design
• Membrane crystallography

Invited speakers and tutors:

• Paul Adams, Berkeley, USA
• Pavel Afonine, Berkeley, USA
• Armando Albert, Madrid, Spain
• Jose M Carazo, Madrid, Spain
• Kay Diederichs, Konstanz, Germany
• Paul Emsley, Cambridge, UK
• Rafael Fernández-Leiro, Madrid, Spain
• Carmelo Giacovazzo, Bari, Italy
• Xavier Gomis-Ruth, Barcelona, Spain
• Juan A. Hermoso, Madrid, Spain
• Eugene Krissinel, Oxford, UK
• Jose. A. Marquez, Grenoble, France
• Airlie J. McCoy, Cambridge, UK
• Rob Nicholls, Cambridge, UK
• Santosh Panjikar, Australia
• Maria Solá, Barcelona, Spain
• Isabel Usón, Barcelona, Spain

The MCS2018 is directed to 25 graduate students and/or researchers with some previous expertise in crystallography which need a deeper insight into most advanced crystallographic techniques to carry out their research projects. The school program covers aspects such as sample preparation, phasing, model building, crystallographic refinement, validation, and analysis of the structural results, as well as an overview on the newest technologies.

We are planning to include an extra day on May 20th devoted to Fundamentals on Crystallography by Carmelo Giacovazzo. Applicants interested in attending to this extra day, please indicate it so in both, the registration letter and registration form.

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Exploring the Capability of Cryo-EM to Provide Insight Beyond Static Structures of Macromolecules

Workshop No. 4 at the ACA Annual Meeting (20-24 July 2018)

Confirmed Instructors:
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Angela Criswell, Rigaku Corporation
Srinivas Chakravarthy, BioCAT Group, Advanced Photon Source
Richard Gillilan, Macromolecular Diffraction Facility, Cornell High Energy
Synchrotron Source
Thomas Grant, University of Buffalo/Hauptman-Woodward Medical Research
Institute
Jesse Hopkins, BioCAT Group, Advanced Photon Source
Maxim Petoukhov, BIOSAXS Group, EMBL Hamburg

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This practical crystallization course is meant for undergraduates, postgraduates and postdocs with an interest in macromolecular crystallization. The course consists of theoretical lectures, seminars, practical work and demonstrations, with a focus on protein crystallization.Â

Participants of the course are encouraged to present their own work at the planned poster section.Â

Applications deadline for attending the course is 31st March 2018.Â

For further information and contact form, please visit:Â Â https://macromolcryst2018.febsevents.org/

The workshop is dedicated to Integrative Structural Biology

The main objective of this workshop is to offer a theoretical and practical training in the different techniques used in integrative structural biology (X-ray diffraction, small-angle X-ray scattering, NMR, cryo-electron microscopy, sample preparation for structural biology, biophysical methods to study and characterize macromolecular interactions). The goals are to explain and illustrate, to an audience mainly composed of doctoral students and young researchers, the contributions and limitations of each method with a strong emphasis on their complementarity and future developments.
The official language of the workshop is French but presentations may be given in English, depending on the overall profile of the students. For practicals, English and French speaking groups may be organised.

Deadline for registration: April 9, 2018 (maximum number of participants: 25)

More information on the French Initiative ReNaFoBiS : http://www.renafobis.fr/

A CRUK Centre Network Meeting

This free one-day meeting is open to anyone with an interest in the use of structural biology and fragment-based hit finding to accelerate drug discovery in oncology and beyond.  There are opportunities for poster presentations and short talks and we are keen to have lab-active researchers attend.

Highlights include:
Plenary Speaker: Peter Parker, “Mechanisms, Monitoring and Medicines”
Sessions on “What makes a good target”, “Fragment approaches” “Success stories”.
Lunchtime panel discussions on “Getting your protein into a drug discovery programme”, “How to find your first hit” and “Funding opportunities”

We are pleased to announce that the next ''Atelier de BioCristallographie 2018'' organised by the University Paris-Saclay, the Ecole Polytechnique (Marc Graille), the University Paris-Sud (Inès Gallay), the Synchrotron SOLEIL (Serena Sirigu), and the I2BC (Julie Ménétrey and Marie-Hélène Le Du) will be held at the Synchrotron SOLEIL (Saint Aubin, France) from the 9th to the 13th of April 2018.

The course is aimed to French speaking PhD students, post-doctoral fellows, researchers and engineers who already know the basics but wish to deepen their knowledge of X-ray crystallographic structure determination of biological macromolecules.

The workshop will include morning lessons and afternoon practicals and will cover the following program:

• Crystal freezing
• X-ray data collection and processing on the Proxima1/2 Beamline at the Synchrotron SOLEIL
• Phasing (Anomalous Dispersion and Molecular Replacement)
• Structure refinement and validation

The participants are expected to attend the MOOC “Voyage au cÅ"ur du vivant avec les Rayons X : la Cristallographie” prior to attending the workshop.

Registrations are limited to 12 participants and will be closed on February 16, 2018.

Diamond is pleased to present its fourth monthly Synchrotron User Webinar. This webinar is aimed at the User Community from PIs to students. It will be broadcast live online and will allow viewers to submit questions to be discussed.

This month's webinar is on Thursday 25th January 2018 at 16:00 (UTC, London time). The topic will be 'The Changing Landscape of MX' brought to you by the Principal Beamline Scientist of VMXi (Thomas Sorensen) and the Principal Beamline Scientist of I23 (Armin Wagner).

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We invite you to register for this webinar by clicking here. This will enable us to contact you closer to the date with the necessary viewing link.

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Starting at 16:00
- Welcome and introductions - Chairperson - Laura Holland
- VMXi beamline update - Principal Beamline Scientist of VMXi - Thomas Sorensen
- I23 beamline update - Principal Beamline Scientist of I23 - Armin Wagner
- Discussion - Panel: T. Sorensen and A. Wagner
- Upcoming available training and events in MX and conclusions - Chairperson - Laura Holland

Ending by 17:00

This international workshop is a forum for presenting and discussing results from state-of-the-art experimental approaches (including optical spectroscopy, NMR spectroscopy, X-ray crystallography, XFELs, electron microscopy, atomic-force microscopy and scattering methods), and theoretical and computational methods to studying protein dynamics.

The Les Houches â€" TSRC Protein Dynamics Workshop complements the long-standing TSRC Protein Dynamics Workshop, held every other year in the odd calendar years at the Telluride Science Research Center in Telluride, Colorado.

In Les Houches, about 30 invited speakers will give oral presentations that comprise a pedagogic introduction to the methodology employed, followed by applications from their own work. Each 30-minute presentation will be followed by 15 minutes of discussion. In addition to the 30 invited speakers, there will be space for 30 student/postdoctoral participants that can present posters.Its relatively small number of participants favors exchange of ideas across disciplines and fostering of collaborations.A few slots for oral presentations are still available.

The Ecole de Physique des Houches can be conveniently reached from Geneva Airport (including the train station at the airport with direct connections to Zurich) by shuttle-bus service within 80 minutes.

The course has two parts: half a day devoted to lectures on April 5 morning, in the Biocev auditorium - no registration is needed, everyone is welcome to attend the presentations and lectures given by:
Jan Dohnalek (IBT Biocev Vestec)
Andreas Heine (IPC Marburg)
Bohdan Schneider (IBT Biocev Vestec)
Tomas Koval (IBT Biocev Vestec)
Petr Pompach (CMS IBT Biocev Vestec)
Manfred Weiss (Bessy II)
Sameer Velankar (to be confirmed, or another speaker from EBI)
John Darby (Chemistry, U. of York)

The remaining part of the workshop (three half days, April 5 afternoon, April 6 morning and April 6 afternoon) consist of a "workshop", hands on sessions for 16 registered participants. This part will be dealing with

• The initial pre-screening using biophysical methods (Tatsiana Charnavets, CMS)
• Dispensing target protein crystals to a fragment library (Jiri Pavlicek, CMS)
• In situ testing of crystal diffraction, data collection and evaluation of the results (Jiri Pavlicek, CMS)

Deadline for submission of applications is February 9, 2018

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This workshop is particularly targeted for PhD students and postdocs having projects aimed at 3D structure determination using biomacromolecular crystals, working at institutes that are members of SESAME and/or working at institutes of Instruct-ERIC countries relatively far from European Synchrotrons, as well as for students from non-EU countries working at EU-institutes who need to apply for visa, restricting efficient access to perform on-site data collection. Students are encouraged to send crystals in advance, which will then subsequently be shipped to DLS or ESRF and used as examples for remote data collection.

The EU-funded structural biology project iNEXT provides free user access to some of the most advanced facilities for structural biology in Europe: X-ray synchrotron sources, high-field NMR facilities, Electron Microscopy, and other imaging and biophysical characterization facilities.

The 3rd Annual Users Meeting of iNEXT will take place at the European Photon and Neutron (EPN) Science campus in Grenoble (France). The meeting is intended to bring together iNEXT users of the various facilities, and iNEXT partners to exchange on recent scientific advances made in the field of structural biology. It also provides a unique opportunity to discuss the access modalities to iNEXT facilities and to make suggestions for future improvements.