The goal of this workshop is to teach new cryo-EM users how to prepare samples for imaging on cryo electron microscopes, primarily through hands-on tutorials, discussions and introductory talks.

Topics

The NYC Computational Cryo-EM Summer Workshop brings together applied mathematicians, software developers, and experimentalists from the field of cryo-EM to advance the state of data analysis and processing. This includes development of new algorithms and software, as well as identifying new problems introduced by recent experimental techniques.

Specific topics include:

• advances in reconstruction algorithms,
• software implementations and automation,
• motion correction,
• 2D and 3D classification and continuous heterogeneity analysis,
• related mathematical results, and
• new challenges.

Stanford-SLAC Cryo-EM Center (S2C2) will host a three-day Cryo-EM Modeling workshop on July 10-12, 2019. This workshop, the third in a series, will cover the basic principles and practical protocols to obtain atomic models based on cryo-EM density maps at near atomic resolution.

 The workshop will be conducted by experts in the field of map visualization, density segmentation and annotation, model building, model optimization, and ligand fitting. Special attention will be devoted to validation tools that ensure model reliability and acceptability for deposition to map and model databases.

The workshop agenda can be found at:Â Â https://cryoem.slac.stanford.edu/s2c2/training/workshops

 There is no registration fee for this workshop, but in-person attendance is limited to 40 participants.

The meeting will be held at the Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Workshops will take place on Sunday the 3rd of November, followed by a welcome reception. Scientific sessions and exhibition will be held on Monday the 4th and Tuesday the 5th of November, with a conference dinner in central Cambridge on the 4th.

Scientific talks will cluster around the following major themes:

• structure and biophysics based drug design stories
• cryoEM in a pharmaceutical setting
• popular biophysics techniques, eg. HDX-MS
• popular drug discovery trends, eg. degraders

Workshops will include three consecutive sessions about biophysics, crystallography and cryoEM.

Important dates:

• Early Bird registration closes 22nd July 2019
• Registration closes: 28th October 2019

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 Biomedicum, Karolinska Institutet

The 2nd CryoNet Annual Symposium will highlight the latest discoveries in protein-nucleic acid complexes along with a view to the future of cryo-EM. Alongside presentations on important biological results will be exciting methodological advances emphasizing that cryo-EM is still in a major growth phase.

Students and postdocs are encouraged to apply to give talks and poster presentations

CryoNet is funded by the Knut and Alice Wallenberg Foundation and the Novo Nordisk Foundation

To be held at Birkbeck College, University of London

The aim of the course is to teach the basic principles and practical aspects of image processing to structural and molecular biologists wishing to determine macromolecular structures by cryo EM. The course will concentrate on processing of high-resolution image data, for both single particle images and tomograms, and will be aimed at advanced PhD students and postdocs using cryo EM for structural analysis.

The VU Amsterdam and the Dutch Crystallographic Society (NVK) will host a 1-day Structural Biology Symposium. During this one day symposium new results and key questions and issues in structural biology and imaging will be addressed, in particular:

• High-resolution 3D structures of macromolecules and macromolecular complexes using X-ray diffraction, Cryo-EM and Electron microdiffraction
• Protein-Protein and Protein-Nucleic acid interactions
• Drug design
• Diffuse Scattering

The programme will address the limiting step in structural studies - the production of
pure and homogenous proteins. Talks and discussions at this event will explore strategies
to optimize membrane and soluble proteins for crystallization, cryo-EM and NMR studies.
Discussions will include construct optimization, novel thermostability assays,
crystallization tools and `tricks of the trade' to enable structure determination.

This event is particlarly directed toward early-stage graduate students in structural biology.
However, anyone interested in generating soluble proteins for a variety of applications,
such as enzymatic assays and antibody production, would be welcome to attend.
Manufacturers of instruments and techniques to assay purity and homogeneity
will be available for hands-on demonstrations.

The list of invited speakers are experienced in the structure determination of
membrane proteins, cytosolic/secreted proteins, and macromolecular signaling complexes:

Edmund Kunji, Cambridge
Daniel Panne, Leicester
Maria Sasi Conte, King?s College
Naomi Chayen, Imperal College
Laura Itzhaki, Cambridge
Chris Tate, Cambridge

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With workshops:

• SDM3: Diffraction : Cristallographie et Microstructure
• SC4: Modeling and Data analysis
• SDV1: Cryo-EM

This one-day scientific symposium will highlight the role cryo-EM can
play in the drug discovery process. Leaders in the biopharma industry
will highlight their successes and experiences utilizing this
ground-breaking technology.Â

 Topics include:

       * Cryo-EM in Biopharma: Progress and Lessons Learned
       * Cryo-EM by Outsourcing: Panel Discussion
       * Bottlenecks: Sample preparation, Throughput, Data Infrastructure
       * Hot Topics: micro-Electron Diffraction

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To held held at MIT Samberg Conference Center

The organization hosting this workshop is The Hong Kong Jockey Club University of Chicago Academic Complex | The University of Chicago Francis and Rose Yuen Campus in Hong Kong, Ben May Institute for Cancer Research and Department of Biochemistry and Molecular Biology, The University of Chicago.

Scientific topics

• Macromolecular complexes

• Structural dynamics

• Ion channels

• Building a sustainable cryoEM community

The workshop will be held at the Hong Kong Jockey Club University of Chicago Academic Complex / The University of Chicago Francis and Rose Yuen Campus

The Pacific Northwest Cryo-EM Center (PNCC) will be hosting a hands-on workshop August 12-30 (right after M&M in Portland wraps up). The 3-week workshop is focused on providing students ample hands-on training and practice with every step of the single-particle workflow, from sample vitrification, to microscope operation, to data collection and processing.  This hands-on training is paired with online content and videos created by the Jensen group in collaboration with Matthjin Vos at Thermo-Fisher, and Peter Shen and Janet Iwasa at University of Utah. As a whole, the course is designed to maximize the effectiveness of student?s time while at the instrumentation so that they achieve independence as cryo-EM practitioners.  The instrumentation that will be available for training includes: TFS Vitrobot, Leica GP2, Talos Arctica, Titan Krios, Falcon 3, K2 and GIF-K3 cameras. We plan to restrict this workshop to 12 students, and start offering the workshop up to 4 times per year, depending on demand.

We would like the course attendees to include those may be new too, or interested in starting, with cryo-EM. If you know such a potential candidate, please pass this along to them. We will start taking applications April 1st through 14th from our website, http://pncc.online.

Owing to the generosity of the NIH Common Fund that created PNCC, the course is heavily subsidized and a $3,000 course fee is intended to cover lodging, ground transportation, breakfast and lunch so that students and trainers can focus on learning effectively as a team.

You’re invited to the 77th Annual Pittsburgh Diffraction Conference at Oak Ridge National Laboratory (ORNL), which is located in Oak Ridge, Tennessee (near Knoxville). The conference will take place over three days and feature sessions focused on all areas of diffraction, from powders to protein crystals. Topics will include emerging technologies/techniques, Total scattering, Magnetic scattering, and Integrative Structural Biology. The Chung Soo Yoo Award, established by the Pittsburgh Diffraction Society to honor Dr. Yoo’s memory, and a $400 cash prize will be given to the graduate student having the best poster presentation at the conference.