ECS8, the 2023 European Crystallographic School, is planned as an in-person event.

The school will be held in Berlin, at the site of the BESSY II electron storage ring operated by the Helmholtz-Zentrum Berlin.

Up to 100 young international students and scientists will have the chance to meet with renowned lecturers and tutors and become acquainted with the most up-to-date principles and applications of X-ray crystallography.

Topics

• Fundamentals of Crystallography
• Single Crystal Diffraction
• Powder Diffraction
• Synchrotron Radiation in Crystallography
• Macromolecular Crystallography
• Applications of CrystallographyÂ

Fundamental lectures will be taught during the mornings. Afternoons will be dedicated to lectures on applications and hands-on tutorials.

Application for ECS8 is open until 28 February 2023.

Decades of careful experimentation and analysis by biophysical chemists
have formed a foundation for contemporary scientists to understand the
structure and function of proteins in the incredibly complex environments
of living organisms. Recent advances in experimental and computational
approaches have made it possible to describe and predict the structure,
dynamics, and interactions of biomolecular assemblies in complex
environments in vitro, in situ, in cells, and in the extracellular
environment. Despite these exciting advances, many challenges remain in
integrating techniques and approaches that span multiple time and length
scales, and in understanding how atomic level changes drive functional
biological outputs in the cellular environment. The symposium will bring
together experimentalists and theorists who apply cutting-edge methods to
determine the structure of biomolecules at or near atomic level precision
in such environments. Speakers will discuss recent progress in the field
and future challenges in the areas (1) atomic resolution studies of large
complexes, (2) biomolecular condensation, (3) in situ studies in cell and
cell-like environments, (4) in vitro cellular environments, and (5)
biophysical experiments in multi-cellular environments.
 
The abstract deadline is October 17, 2022

Since 2014, the Hot Topics in Contemporary Crystallography (HTCC) workshops have tackled the most fascinating achievements in both experimental methods and theoretical approaches that have recently brought structural research to the forefront of natural sciences. HTCC 5 will explore structural research of biological macromolecules (proteins, nucleic acids and complexes) from a highly practical perspective, putting special emphasis on crystallization, data processing and database (PDB and NDB) digging.

The lecturers are a mix of academic researchers, university teachers, software developers and dedicated equipment manufacturers with a rich history of practical work in and around macromolecular crystallography. Students - from both industry and academia - will be encouraged to present their own work, either on a poster or by holding a short discussion-triggering presentation (DTP). In addition, they are encouraged to bring any protein (or nucleic acid) samples that have been found to be particularly resistant to crystallization to the workshop, where they will benefit from state-of-the-art technology and expert help.

This workshop will be held at the MicroED Imaging Center at UCLA and will contain both lectures and hands on demonstrations and training. It is open to both academia and industry. The cost for academic attendees is $500. The cost for attendees outside academia is $1,500.
 

Topics covered

• Sample preparation methodologies for proteins and small molecules
• MicroED data collection
• Camera performance
• Cryo-FIB-milling procedures for MicroED
• Data analysis software, structure solution, and refinement

This workshop is being held as part of a suite of workshops during the SSRL/LCLS Annual Users' Meeting.

There is no cost to attend.

 

Organized by the German Society for Electron Microscopy

There are highly prominent plenary speakers from the Material and Life Science EM community scheduled:
Ralf Bartenschlager (Heidelberg/DE)
Sarah Heigh (Manchester/UK)
Peijun Zhang (Oxford/GB)
Mathieu Kociak (Paris/FR)

In-person only. 10am-5pm with networking 5pm-6.30pm AEST.

This course is largely aimed at structural biologists with high/medium resolution EM maps for modelling building and refinement. This four-day course (6th-9th September) will host some of the leading software developers and provide ample contact time to allow delegates to discuss their data in detail alongside traditional lectures and tutorials. This is a comprehensive course for EM model building covering advanced use of ARP/wARP, Buccaneer, CCP-EM, Coot, FlexEM, ISOLDE, LocScale, MolProbity, Refmac, Privateer and new validation tools. It will cover all aspects of modelling building including: map optimisation, automated model building, medium-resolution refinement, high resolution refinement, interactive refinement, validation and deposition.
 

The course will be held at the RAL / Diamond campus, Harwell, UK, site of the eBIC national facility. Registration fee is £360.00 and we will provide food and three nights accommodation. Delegates are asked to meet their own travel costs.
 

The course is limited to 20 delegates which will be selected from all applicants. A maximum of 40 applicants can register interest.
 

* Confirmed tutors / topics:

Arjen Jakobi, Alok Bharadwaj (TU Delft) : LocScale

Kevin Cowtan, Soon Wen Hoh (University of York) : Buccaneer

Grzegorz Chojnowski (EMBL) : ARP/wARP, findMySequence, checkMySequence

Judit Debreczeni (Astrazeneca), Lucrezia Catapano (MRC-LMB Cambridge) : Coot

Keitaro Yamashita, Rangana Warshamanage, Rob Nicholls (MRC-LMB Cambridge) : REFMAC, Servalcat, EMDA

Maya Topf, Tristan Cragnolini, Aaron Sweeney (CSSB Hamburg) : Flex-EM, TEMPy

Tristan Croll (University of Cambridge) : ISOLDE

Jon Agirre (University of York) : Privateer

Jane Richardson (GCB Duke) : Model validation, Molprobity

Jack Turner (EBI) : EMDB

Mihaly Varadi (EBI) : AlphaFold-DB, 3D-Beacons

* Registration:

https://urldefense.com/v3/__https://cvent.me/42xnY9__;!!Mih3wA!FECYFrFcZ1zLd2iXpFHaabT1MX3mIIYYU37FRgaKyZ-1gwc5YmKLdbLVxho0pkOfgcJ9TDc8lI5N_xwJBS8uaGNczG_kWo5o$

Organized by CERM/CIRMMP Italy centre. 

During three practical sessions (9:00-13:00 CEST) the participants will be
trained on different software for integrating multiple types of Structural
Biology experimental data.
On the final day (13:00-19:00 CEST), renowned researchers in the field will
present examples of studies for which Integration of different techniques
proved to be the only way to achieve their goals. Psychological aspects of
science communication and the philosophical implications of integrative
approaches will also be discussed.

Remote course

June 22th to June 24th (2022) (3 days):
*3 Mornings: Presentations and training.
*2 Afternoons: Personal work.

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Hands-On Training Course that introduces the fundamentals and main tools needed to build an atomic model in the context of cryo-EM, starting from a 3D map and the aminoacid sequence of each protein chain. The tools will be used inside the Scipion framework (de la Rosa-Trevin et al. 2016) and examples will focus on the modeling by homology scenario, including AlphaFold2 prediction models.

Expected impact for young researchers

Atomic models based on high-resolution density maps are the ultimate result of the cryo-EM structure determination process. In this course, we introduce the basic tools needed to perform this task. Ph.D. students, as well as post-docs, will undoubtedly benefit from approaching this technique since atomic models guide our mechanistic interpretation of cryo-EM structures.

 Registration Fee: 50€

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Time: Thursday, May 26, 2022 at 9 AM pacific / 12 PM eastern time
From NIH Transformative High Resolution CryoEM Program sponsored service centers

Speakers: Lorena Saelices Gomez & Binh Nguyen, Center for Alzheimer's and Neurodegenerative
Diseases, Department of Biophysics, UT Southwestern Medical Center.

A four-day VIRTUAL Cryo-Electron Microscopy

This course will introduce high-resolution Cryo-EM to the structural biology research community. It will include image formation and three-dimensional reconstruction theories and available software, tutorials, and demonstrations for data collection and analysis.

Confirmed speakers and instructors include:

David DeRosier, Brandeis University
Chen Xu, Umess
Tamir Gonen,UCLA
Gabriel Lander, Scripps Research
Oliver Clarke, Columbia University
Dongyan Tan, Stony Brook University
Jun Liu, Yale University
Digvijay Singh, UCSD
Jianfeng Lin, Yale University
Raphael Park, Yale University
Muyan Chen, Baylor College of Medicine
Yong Xiong, Yale University
Qun Liu,Brookhaven National Laboratory
Guobin Hu,Brookhaven National Laboratory
Liguo Wang, Brookhaven National Laboratory

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https://www.bnl.gov/cryoemcourse/files/pdf/agenda.pdf

A symposium in Dr. Kenneth Taylor's honor to celebrate his lab's accomplishments and to highlight advances in cryo-EM and muscle research. The symposium will feature many notable National Academy investigators whose research focusses on muscle biology and cryo-EM.

It will run 8:30 AM - 5:30 PM on May 13th and 14th and will be in person only. Lunch and coffee breaks will be provided. Registration is required, and attendance will be capped. Please secure your spot by submitting your registration ASAP here.

Frederick National Laboratory will host a new training program in
Frederick, Maryland, September 12-16 for cancer researchers who want to
build expertise in cryo-electron microscopy. The workshop will cover topics
from grid preparation, imaging, and data processing. This workshop will be
in-person and attendees will have the opportunity to gain hands-on
experience with all stages of the cryo-EM workflow.