The Phenix developers will be holding an online *Phenix User Workshop on
the 7th and 14th of April at 4-9pm PDT.* These times will work best for
researchers in Asia and Australasia.
 

The format of the workshop will be demos of the use of Phenix programs
combined with slides to explain the theory. We expect an interactive
meeting where attendees can ask questions for the Phenix team to answer.

The workshop will cover aspects of macromolecular crystallography
in Phenix, with the final emphasis based on the applicants’ research
interests. 

*AGENDA:*
*7 APR *

 - 3.45pm - Start of Zoom session (for people to debug any issues)
 - 4.00pm - Paul Adams - Phenix Overview
 - 4.30pm - Tom Terwilliger - Map Improvement
 - 5.45pm - Tom Terwilliger - Model Building
 - 7.00pm - Question/Answer session

 

*14 APR *

 - 3.45pm - Start of Zoom session (for people to debug any issues)
 - 4.00pm - Pavel Afonine - Real Space Refine
 - 5.15pm - Nigel Moriarty - Ligands and Restraints
 - 6.00pm - Jane Richardson - Validation
 - 7.00pm - Question/Answer session

"What can cryo electron tomography and cryo soft X-ray tomography do? From the basics to correlative imaging approaches?

The aim of the workshop is to provide the basics of the techniques, their limitations and opportunities, and extends to cryo-superresolution light microscopy, advanced instrumentation, implementation and data processing.

The event is open to PhD students, Postdocs or any potential user who would like to learn more about cryo-electron tomography and cryo soft X-ray tomography.
 
 

A limited number of places is available, and registration is free on a first come, first served basis.

Upcoming virtual PICO2021 conference organized by the Ernst-Ruska Centre in Juelich.

The conference aims to provide a forum to highlight state of the art developments in computational cryoEM and related themes as well as showcasing outstanding recent biological applications. We aim to promote an inclusive, friendly atmosphere welcoming both old and new to the community. Topics include instrument technology, sample preparation, image processing, single particle reconstruction, tomography and model building. The schedule will also include the Diamond Light Source biological cryo-imaging user meeting for eBIC & B24.
 

Confirmed speakers include:
Alberto Bartesaghi (Duke)
Francesca Coscia (Human Technopole)
Hans Elmlund (Monash)
Radoslav Enchev (Crick)
Misha Kudryashev (Max Planck Institute of Biophysics)
Takanori Nakane (MRC-LMB)
Carlos Oscar Sorzano (CSIC)
Lori Passmore (MRC-LMB)
Maya Topf (Birkbeck / CSSB Hamburg)
Matthias Wolf (OIST)
Peijun Zhang (DLS / Oxford)
Ellen Zhong (MIT)
Plus what's new at CCP-EM, EBI and eBIC

 
 

Registration is free

This webinar on paired refinement to be held on March 23, 2021, from 3 PM (CET) to 4 PM (CET). This protocol provides an accurate estimation of the high-resolution cutoff (https://journals.iucr.org/m/issues/2020/04/00/mf5044/).

The "PAIREF webinar" will be a free virtual event for up to 300 participants.

The meeting will be recorded.

Please register and receive your Zoom link here: https://kipl-indico.fjfi.cvut.cz/e/pairef
Â

It will cover:
1. Introduction to paired refinement.
2. Installation of PAIREF for CCP4 and/or PHENIX users.
3. Short tutorial (files will be provided).
4. Discussion.

Â

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8:00 - 9:30 a.m. (PST).

Speakers:
Prof. Brian Kobilka (2012 Nobel Prize in Chemistry)
Stanford University Medical School
Talk title: "Mechanistic insights from cryoEM enabled structures of G protein coupled receptors"

Prof. Eva Olsson
Chalmers University of Technology
Talk title: "In situ TEM with piezo-driven manipulation, probing and perturbation"
Please register soon at:
https://stanford.zoom.us/webinar/register/WN_eMxleNraRhmREedt141IWw 

We are pleased to announce the virtual Workshop „Strategy for future EMBL research infrastructures in the Life Sciences in Hamburg" taking place on Monday, 29th and Tuesday, 30th March 2021. The aim of this workshop is to explore possible future directions for research and research services in structural biology. All interested scientists (user community, stake holders, funding organisations etc.) are most cordially invited to participate. Details about the workshop can be found at https://indico.embl-hamburg.de/event/2/ Registration is open on a first come first serve basis with a limited number of places available.

Given the current situation and the fact that knowledge dissemination has to continue, the BCS meeting will be an 'open for all', free of charge event. Registration is required for organizational purposes.

First Annual Scientific Meeting of iNEXT-Discovery, is a European project in the area of structural biology, from which you can access several EU centers (X-ray, NMR, cryoEM and 
biophysical technologies).

The virtual meeting brings together world leading scientists, group leaders and young researchers with a keen interest in the latest science occurring at the interfaces of structural biology, biophysics, molecular & cellular imaging and neuroscience. Given its cross-disciplinary nature, the meeting presents a broad overview of molecular neurobiology, ample opportunities for discussions and a sneak peek into the latest developments.

The format of the workshop is online (using Zoom) and is scheduled to take place on March 16, March 17 and March 18 from 12:00 PM (ET) to 6:00 PM (ET) for all three days. There is no fee to participate in the workshop. For each session, there will be up to 9 presentations and 2 discussion sessions. We would like to encourage participation from synchrotron facilities worldwide.
 
 

 Synchrotron Radiation Macromolecular Crystallography has been on the forefront of biological studies requiring access to structural information. It has seen several major updates and new developments ranging from sample standards, robotic sample changers, micro-focus beamlines, pixel array detectors to distributed and automated data processing, and the list goes on. In the last few years, several major facilities began operation and a few more were upgraded to what is the state of the art today. Along these upgrades, all facilities have updated and upgraded equipment, high performance computing and the associated software to allow researchers to continue pursuing the most impactful areas of life science research. In the coming years, more facilities will be upgraded, including two in the US.

All of these advances are required for groups from academia and industry to increase their rate of discovery, relying on either the brightest beams to tackle the most challenging projects, or on higher levels of automation, so that researchers can not only achieve more, but most importantly can invest valuable time in tackling the difficult projects and rely on automation for their other projects.

In this workshop, we will have presentations dealing with sample automation and standards (March 16; chair Jean Jakoncic), about high data rate MX analysis (March 17; chair Dale Kreitler), and on user interfaces and remote access (March 18; chair Martin Fuchs). In all sessions, we will emphasize the current state of the art and planned upgrades. Ideally, we would like the spirit of the workshop to be cooperative, even sparking collaborations to elaborate common solutions to deal with common problems.
If you are interested in contributing at any of the 3 sessions, please send requests to: NSLS-II_MX_2021@bnl.gov

Motivation

About 17-ID-1 AMX Beamline

The beamline offers ultrabright (>4 1012 ph.s-1) x-rays delivered by a canted in-vacuum undulator source (IVU21) with x-ray energies ranging from 5keV to 18keV and a beam size of 7*5 μm2.

The beamline has an adaptable optical system consisting of white beam slits, a double crystal Si(111) monochromator with horizontal theta-axis, tandem flat beam deflecting silicon mirrors (Pd and Si lanes) and Kirkpatrick-Baez focusing silica mirrors, which are Pd coated and able to bent adaptively using 16 piezo actuators.

Each optical element is preceded by slits and its transmitted beam is monitored by beam position monitors or retractable screens.

About 17-ID-2 FMX Beamline

The Frontier Microfocusing Macromolecular Crystallography (FMX) delivers a flux of 3.5x1012 ph/s at 1 Ã... wavelength into a 1x1.5 to 10x10 µm2 (VxH) variable beam focus, covering an energy range from 5 - 30 keV. Its flux density surpasses current MX beamlines by up to two orders of magnitude.

The FMX optical system features a highly stable horizontal bounce Si 111 double crystal monochromator, as well as 16-segment bimorph bending mirrors in a single stage vertical and a dual stage horizontal focusing scheme. More...

Join the Workshop Remotely

The Zoom connection information will be provided to you prior to the start of the event. Please do not give out this connection information. It is only for registered attendees.

Within this Conference there is the Michael G. Rossmann Memorial Symposium which focuses on the application of hybrid methods in electron microscopy of viruses, enzymes and other macromolecules, areas in which Michael was a pioneer.

The symposium will feature invited talks from Prof. Hao Wu (Harvard Medical School), Prof. Rui Zhao (University of Colorado School of Medicine), and Prof. Chuan (River) Xiao (University of Texas El Paso).
 

We invite abstracts from speakers in academics and industry at all career levels who develop and apply cutting-edge structural biology approaches to the study of viruses, viral proteins, enzymes, membrane proteins, and other systems. Ten abstracts will be selected for 15-minute oral presentations whereas the remaining abstracts will have the opportunity to be selected for poster presentations. Please note that the deadline for abstract submission is February 18, 2021. You will have the opportunity to select your preference for either in-person or virtual presentation.

On May 4-5, 2021, a special symposium will be hosted by the American Society for Biochemistry and Molecular Biology.

PDB50 will mark an important milestone in the history of structural biology. In 1971, the structural biology community established the single worldwide archive for macromolecular structure data â€" the Protein Data Bank (PDB). From its inception, the PDB has embraced a culture of open access, leading to its widespread use by the research community. PDB data are used by hundreds of data resources and millions of users exploring fundamental biology, energy and biomedicine.

Structural biology and structural bioinformatics have had an enormous impact on our understanding of the mechanism and function of biological macromolecules. The PDB acts as a custodian for all these data, representing a repository of the vast majority of the achievements and milestones of the structural biology community. The archive is managed by the Worldwide Protein Data Bank consortium (wwPDB) of partner sites in Asia, Europe and America.

This celebration of the 50th anniversary of the founding of the Protein Data Bank as the first open access digital data resource in biology will include presentations from speakers from around the world who have made tremendous advances in structural biology and bioinformatics. Students and postdoctoral fellows are especially encouraged to attend and will be eligible for poster awards.

The online sessions will take place between 11 a.m. â€" 4:30 p.m. EST each day.

The event will be recorded and made available to registered participants after the meeting.

Important dates

Speakers will include:

• Edward Arnold, Rutgers, The State University of New Jersey
• Helen M. Berman, Rutgers, The State University of New Jersey and University of Southern California
• Thomas L. Blundell, University of Cambridge
• Alexandre M. J. J. Bonvin, Utrecht University
• Stephen K. Burley, Rutgers, The State University of New Jersey and University of California, San Diego
• Wah Chiu, Stanford University
• Johann Deisenhofer, University of Texas Southwestern Medical Center
• Juli Feigon, University of California, Los Angeles
• Angela Gronenborn, University of Pittsburgh
• Jennifer L. Martin, University of Wollongong
• Stephen L. Mayo, California Institute of Technology
• Zihe Rao, ShanghaiTech University and Tsinghua University
• Hao Wu, Boston Children's Hospital

Sponsorships

Sponsorship opportunities are available;Â contact the wwPDB Foundation for more information.

Organizers

• Celia Schiffer, University of Massachusetts Medical School
• Helen M. Berman, Rutgers, The State University of New Jersey;Â RCSB PDB
• Stephen K. Burley, Rutgers, The State University of New Jersey;Â RCSB PDB
• Jeffrey C. Hoch, University of Connecticut;Â BMRB
• Gerard J. Kleywegt, European Bioinformatics Institute;Â PDBe
• Genji Kurisu, Osaka University; PDBj
• John L. Markley, University of Wisconsinâ€"Madison; BMRB
• Sameer Velankar, European Bioinformatics Institute;Â PDBe
• Christine Zardecki, Rutgers, The State University of New Jersey;Â RCSB PDB

The BSG Winter Meeting will be held virtually on Friday 18th December. Please see the attached flyer or the BSG webpages (https://bsg.crystallography.org.uk/index.html) for details. In addition to the Zoom Webinar there will be a Remo cafe space for participants to interact between sessions and after the meeting.

Our Winter meeting celebrates Rosalind Franklin’s 100th Birthday with a line-up of world-leading international speakers presenting some of the newest and exciting achievements in structural biology, including a substantial number of presentations related to SARS-CoV-2.We are also delighted that Professor Matthew Cobb from the University of Manchester will open our meeting with a historical account of the life and times of Rosalind Franklin.
 

In addition to organising meetings, a key role of the BCA Biological Structures Group is to promote the development of structural biology, particularly through supporting workshops, training and other events aimed at students and early career researchers. We receive many requests for support and profits from this meeting will be used to support as many of those events as we are able.Please note that we have tried to keep registration costs low. However, if you are a student and/or young researcher and are in need to support to attend this meeting then please contact our secretary Dr. Mark Roe (M.Roe@sussex.ac.uk) to discuss your circumstances.

Following ground-breaking developments in 2018 (CASP13), CASP14 will 
present another round of exciting progress in the field. The conference 
will be virtual and will run from November 30 through December 4, 2020.

There will be a limited number of talks and discussions each day, 
lasting a total of not more than 4 hours. The session times are 
10:00AM-2:00PM (EST); 16:00-20:00 (CET). Poster breakouts and extra 
discussions will be arranged before and after the formal sessions.

The purpose of the conference is to analyze and discuss the outcome of 
the CASP14 community experiment. Assessors will report on the accuracy 
of protein structure modeling in a number of categories, including 
three-dimensional structure, structure refinement, modeling of protein 
complexes, and the ability of models to provide functional insight. Deep 
learning has already made a major impact in this field and will be a 
theme of the meeting. In addition to the assessments, there will be 
talks from modeling groups, posters, round tables, and extensive 
discussions. The program is being finalized and will be available on the 
Prediction Center website.

We hope that the conference will generate ongoing interest group 
activities. There will be a follow-up in-person meeting next summer, 
Covid-19 permitting.