Events
Training courses
MXIS 2015. Practical course on in-plate crystallography and in situ diffraction
| - |
In Grenoble
MXIS training course is dedicated to in situ protein crystallography. This 3-day workshop will include full lectures at the IBS and practical sessions at the ESRF, on beamlines FIP-BM30A and BM14. Full classes will be done in day 1 while practical sessions will be organized in subgroups that will be rotating from day 2 to day 3 (topics: ligand coating, crystallogenesis, in situ diffraction for crystal screening and structure resolution, in situ data processing). Possibility will be given to participants to practice on their own samples.
BioCAT Advanced SAXS Training Course
| - |
In Chicago IL
16th BCA/CCG Intensive Teaching School in X-Ray Structure Analysis
| - |
In Trevelyan College, Durham
Structural Bioinformatics. An EMBL-EBI course
| - |
In European Bioinformatics Institute, CB10 1SD
Day 2 - Tuesday 13 October - New structures from old
Day 3 - Wednesday 14 October - Genetic variation and protein structure
Day 4 - Thursday 15 October - From structure to function
Day 5 - Friday 16 October - Small molecules with big effects
MX Bag Training
| - |
In Diamond Light Source
The Diamond Light Source Macromolecular Crystallography group would like to invite both our academic and industrial users to MX beamline training sessions on the 15th -16th July 2015.
The aim is to provide MX users with sufficient training to be able to operate any of the Diamond MX beamlines efficiently and to get the most benefit from their beamtime. The training will involve hands-on sessions on the suite of five operational MX beamlines (http://www.diamond.ac.uk/mx-home/) as well as optional offline software sessions.
Sessions include:
15th July, afternoon session and 16th July, morning session on MX beamlines:
• MX software: automation in data analysis
• Mini-Kappa goniometry / Anomalous data collection
• Sample humidity control (HC1) • I24 new end station/ In-situ diffraction
• Fragment screening â€" I04-1/Lab36
• Experiment database: new ISPyB
16th July afternoon optional session Hands on software:
Two tutorial sessions:
• CCP4: structure solution and model building with CCP4 (CCP4 team)
• Manual processing with iMosflm (Harry Powell)
IKZ Summer Course on Crystal Growth 2015
| - |
In Berlin
Defect formation during crystal growth from melt and selected epitaxial processes
This lecture course gives an overview of the important defect types, their origins and interactions during the bulk crystal growth from the melt and selected epitaxial processes. The equilibrium and nonequilibrium thermodynamics, kinetic and interaction principles are considered as driving forces of defect generation, incorporation and ensembling. Results of modeling and practical in situ control are presented. Strong emphasis is given to semiconductor crystal growth since it is from this class of materials that most has been first learned, the resulting knowledge then having been applied to other classes of material. The treatment starts with melt-structure considerations and zero-dimensional defect types, i.e. native and extrinsic point defects. Their generation and incorporation mechanisms are discussed. Micro- and macro-segregation phenomena - striations and the effect of constitutional supercooling - are added. Dislocations and their patterning are discussed next as a central course theme. The role of high-temperature dislocation dynamics for collective interactions, like cell structuring and bunching, is specified. Additionally, some features of epitaxial dislocation kinetics and engineering are illustrated. Next the grain boundary formation mechanisms, such as dynamic polygonization and interface instabilities, are discussed. The interplay between facets, inhomogeneous dopant incorporations and twinning is shown. Finally, second phase precipitation and inclusion trapping are discussed. The importance of in situ stoichiometry control is underlined. Generally, selected measures of defect engineering are given at the end of each chapter. Monday, 13.07.2015, 09:00 - 11:00 Overview, melt structure and point defect formation Monday, 13.07.2015, 14:00 - 16:00 Dislocation background and definitions Tuesday, 14.07.2015, 09:00 - 11:00 Dislocation dynamics Tuesday, 14.07.2015, 14:00 - 16:00 Grain boundaries, faceting and twinning Wednesday, 15.07.2015, 09:00 - 11:00 Second-phase particlesProf. Peter Rudolph, Professor Dr. habil, Dr. Ing., was born at July 1st, 1945 in Gera (Germany). After high-school graduation 1964 in Berlin and subsequent study at the Technical University of Lviv (Ukraine) he received the Diploma of Electronic Technology in 1969. The PhD (Dr. Engineer) of Solid State Physics and Technology he obtained at the same university in 1972. From 1973 to 1993 he was employed at the Institute of Crystallography and Material Science of the Humboldt University in Berlin. In 1978 he prepared μg-crystal growth experiments for the first German manned space flight. In 1979 he obtained the DSc (Dr. habil) of Crystallography at the Humboldt University. Here, in 1980 he became the head of the Laboratory of bulk Crystal Growth and in 1985 the university professor position. From 1991 to 1993 he was member of the expert group of the ESA on μg-melt growth experiments. From 1993 to 1994 and in 1998 he held guest professorships at the Institute for Material Research of the Tohoku University in Sendai (Japan). During these times he also co-laborated with numerous Japanese Companies. Then, from 1994 to 2011 he was employed at the Leibniz Institute of Crystal Growth (IKZ) in Berlin. After his retirement in 2011 he is still related active as crystal technology consultant (CTC) for research and industry. He published about 300 original papers, reviews, book contributions, and is co-author of 35 patents. Recently he edited the 2-nd volume of Elsevier´s Handbook of Crystal Growth. He held diverse guest lecture courses in more than 15 countries around the world. He acted also as lecturer of several International Schools on Crystal Growth of the IUCr and IOCG. Peter Rudolph has held various functions in the VfK (secretary), DGKK (president, head of working group), IUCr and IOCG (executive committee). In 2001 and 2008 his former teams won the Innovation Prize of Berlin-Brandenburg.
Â
Neutrons and Synchrotron Radiation for Magnetism. Hercules Specialized Course HSC18
| - |
In Grenoble
   Practicals will take place at the European neutron (ILL) and synchrotron radiation (ESRF) facilities located in Grenoble.
   The attendance will be limited to 24 participants (mainly PhD students and post-doctoral researchers) to allow an active participation in the practicals, a strong interaction between the participants and the lecturers, as well as among the participants themselves.
PPXRD-13. XRD Training for the Pharmaceutical Scientist!
| - |
In Bad Herrenalb
Third training course on symmetry and group theory
| - |
In Osaka
Third training course on symmetry and group theory
Osaka, Japan, 3-7 August 2015
Aim and targetThis training course aims at providing a solid background in symmetry and group theory to students and scientists working on crystalline materials.
Pre-requisitesThe participants are expected to know basic matrix algebra (how to multiply matrices and vectors, how calculate determinant and trace of a matrix: however, the first session of the training course is devoted to revise these notions), fundamental electromagnetism (waves, diffraction) and basic chemistry.
ProgramThe training course will span five full days, from 3 to 7 August, 2015.
Exercices proposed during the whole course are integral part of the course: participants are requested to actively take part in solving the proposed exercises. Evening sessions are also proposed for discussion, practicals, solution to the exercises, questions & answers.
Didactic material will distributed during the lectures and also made available in electronic form.
Monday, 3 August
- Matrix algebra
- Abstract algebra and the notion of group
- Introduction to crystallographic symmetry and lattices
- Evening: welcome reception
Tuesday, 4 August
- Morphological symmetry
- Stereographic projection, with exercises
- Crystallographic point groups and geometric crystal classes
- Symmetry elements with a translational component (screw axes and glide planes)
- Introduction to space groups: basic notions and the Hermann-Mauguin symbolism
- Graphical construction of space groups
- Evening (20:00-23:00): on-demand practicals, questions & answers optional session
Wednesday, 5 August
- Practicals on the graphical construction of space groups
- Metric tensor and applications
- Matrix representation of symmetry operations
- Change of axial settings and alternative settings of space groups
- Evening (20:00-23:00): on-demand practicals, questions & answers optional session
Thursday, 6 August
- Normalizers
- Chirality
- Wyckoff positions, wyckoff sets
- Factor groups, symmorphic groups
- Crystallographic orbits
- Evening (20:00-23:00): on-demand practicals, questions & answers optional session
Friday, 7 August
- Reciprocal lattice and systematic absences
- Group-subgroup relations
- Structure-substructure relations and applications to displacive phase transitions
Coffee break will be served at 10:30 a.m. and 4 p.m. Lunch break will be from 12:30 p.m. to 2 p.m. Dinner from 6 p.m.
Language
The official language of the training course is Japanese. No simultaneous interpretation will be provided.
Venue
The training course will be held at the Institute for Protein Research, Osaka University, seminar room at the first floor.
Lecturer
Prof. Massimo Nespolo, Université de Lorraine, France (on behalf of MaThCryst)
Local Organizing Committee
Dr. Maki Okube, Tokyo Institute of Technology
Prof. Takashi Kamiyama, KEK, Tsukuba
Prof. Noriyuki Igarashi, KEK, Tsukuba
Coordinator
Prof. Genji Kurisu, IPR, Osaka
Lodging, financial support and registration
Participation is free of charge. Details about lodging, application for financial support and registration form are available at the Japanese website .
The Organizers of the trainng course will observe the basic policy of non-discrimination and affirm the right and freedom of scientists to associate in international scientific activity without regard to such factors as citizenship, religion, creed, political stance, ethnic origin, race, colour, language, age or sex, in accordance with the Statutes of the International Council for Science. At this course no barriers existe which would prevent the participation of bona fide scientists.
Residential School on Medicinal Chemistry and Biology in Drug Discovery (ResMed): A Comprehensive One-Week Course
| - |
In Madison, NJ
The purpose of the School is to provide a strong background in the principles of drug discovery and development to enhance collaborative drug discovery programs. Previous attendees with backgrounds in macromolecular crystallography have found the course of great value in their research projects.
ISBIO 2015. Second edition
|
In Caparica, Lisbon
Integrative Structural Biology tools for the study of protein-ligand interactions
EMBO Practical Course on High Throughput methods for protein production and crystallization
| - |
In Marseille
Mantid Training Courses 2015
| - |
In ISIS, Didcot
Mantid Training Courses Feb 2015
Following the success of our previous sessions of these training courses we would like to offer them again in February 2015. These courses are open to both facility staff and any interested people from other institutions.
The following courses will be based at ISIS, RAL and are:
Monday 16th February 1-5pm: Mantid Introduction An introduction to the Mantid interface, how to graph and visualize your data, manipulate it with the built in algorithms, together with an introduction to curve fitting and live data analysis.
Tuesday 17th February 9-12am: Introduction to Python This half day course will introduce you to the Python scripting language, no previous experience required, although some understanding of loops and conditional if statements will be expected.
Tuesday 17th February 1-5pm: Python in Mantid This course concentrates on using Python to build analysis scripts within Mantid as well as controlling the Mantid GUI from python, and accessing the underlying data within Mantid workspaces.
Wednesday 18th February 9-5pm: Extending Mantid using Python For the more adventurous among you this course will introduce you to the many ways you can use Python to extend the capabilities within Mantid adding Python Algorithms and curve fitting functions, as well as diving deeper into the structure of workspaces. After the feedback from the previous run this course has been extended to a full day course, together with adding more material.
Booking a place If you are interested in any other these courses please send an email to nick.draper@stfc.ac.uk letting me know which ones you wish to attend. For the courses we will supply PCs, so there is no need to bring a laptop unless you really want to. Spaces are limited to 13 people per course so please book early to avoid disappointment. If a course is over booked we will try to arrange another session in the future, so if you cannot make that specific date let me know and I’ll let you know about any subsequent courses. I’ll send out calendar appointments to you once your place on the course is booked.
For visitors from UK academic institutions: Are sometimes able to offer assistance with travel and lodging costs while attending the courses. Let me know when you are booking the courses and I’ll get back to you with details. If we are able to help, then you travel and hotel must be booked through the ISIS user office.
For visitors from elsewhere: While we can offer this course for free, we cannot unfortunately offer any help with travel or subsistence costs. However please let me know that you will be visiting when you reply so that I can arrange site access.
ICDD X-ray Diffraction Clinics: Session II - Advanced Methods in X-ray Powder Diffraction
| - |
In New Orleans, LA
Session II - Advanced Methods in X-ray Powder Diffraction
- Brief review of fundamentals
- Factors affecting accuracy of measured 2theta values: intensity aberrations, specimen displacement, specimen transparency, diffractometer alignment, and the use of external and internal standards
- Factors affecting intensities of diffraction peaks: structure-sensitive properties, specimen-sensitive effects, and measurement-sensitive effects
- Use of computer methods for data reduction and qualitative phase identification: peak-hunting methods, alpha2 stripping, search/match techniques and the Powder Diffraction File™, use of elemental data, error windows and probability searching, and scoring algorithms
- Advanced data mining with the PDF
- Exploration of powder pattern indexing methods
- Quantitative analysis: specimen preparation considerations, Reference Intensity Ratios, absorption correction methods, matrix-flushing methods, and whole-pattern analysis using the Rietveld method
- Structure solution and refinement using the Rietveld method
ICDD Clinics on practical X-ray fluorescence
| - |
In Newtown Square, PA
Lectures
- Fundamentals of X-ray Physics
- WDX and EDX X-ray spectrometry instrumentation
- Qualitative and semi-quantitative analysis
- Introduction to quantitative analysis
- Types and sources of error
- Precision and accuracy
- Calibration strategy
- Drift, line and interelement correction application
- Fundamental parameters
- Maintaining instrument integrity
- Specimen preparation
- Submit YOUR SAMPLES for analysis by the experts. Selected results will be the basis for class discussion. Results not presented during class can be discussed in private with the faculty throughout the clinic.
Workshops:
- XRF instrumentation, components, scope, and comparison using live and disabled WDX and EDX instrumentation.
- Selection of parameters for operation
- Demonstration of personal computer exercises in qualitative and semi-quantitative WDX and EDX analysis
- Demonstration of personal computer exercises employing polynomial regression, line overlap, empirical and fundamental parameter corrections during calibration
- Specimen preparation lecture and demonstration of the use of mixers, grinders, presses, fusion apparatus, etcetera
- Discussion of problems encountered by participants
EMBO Practical Course. Small angle neutron and X-ray scattering from proteins in solution
| - |
In Grenoble
This EMBO Workshop will cover the use of small angle scattering (SAS) of both neutrons and X-rays for the determination of the structures of biological macromolecules. Particular attention will be paid on this course to sample preparation and the analysis and interpretation of SAS data in a biological context. The aim of this course is to enable the participants to maximise the information gained from the SAS technique in their future experiments.
Small angle scattering is a powerful technique for determining the structures of biological molecules in solution. Not only can small angle scattering provide precise information concerning the size, molecular weight, volume and shape of single molecules but it can also provide detailed information from large, multi-component macromolecular complexes. For these purposes the scattering properties of neutrons are particularly well suited. Through the use of specific isotope labeling techniques and solvent contrast variation it is possible to determine the structural organisation of specific components within a large macromolecular assembly.
Taking advantage of the location of the European Synchrotron Radiation Facility (ESRF) and the Institut Laue Langevin (ILL) on the same scientific campus in Grenoble, this course will focus on the complimentary use of X-ray and neutron small angle scattering for the determination of the structures of biological macromolecules. Through the use of lectures, tutorials and practicals it is intended to teach scientists new to the technique how to optimize their experiments to gain the maximum amount of information from these techniques. In particular the course will focus on:
- Small angle scattering theory
- Sample requirements for a successful small angle scattering experiment
- Data analysis, model building and interpretation
- Isotope labelling strategies for small angle neutron scattering
- Analysing small angle scattering in conjunction with data obtained from other techniques (NMR, AUC, EM, SEC-MALLS)
Register by: 1 March 2015
APS Data collection workshop and CCP4 school: From data collection to structure refinement and beyond
| - |
In Argonne National Laboratory
8th annual CCP4 USA Crystallography School
The first two days will be dedicated to data collection and processing. The rest of the school will focus on structure solution, refinement and validation.
The course is intended mainly for graduate students, postdoctoral researchers and young scientists in the area of structural biology from all across the globe. The school is not meant as an introductory level course to protein crystallography. It is designed more for applicants with reasonable expertise in crystallography and experience with the CCP4 suite. The purpose of the school is to address specific problems that the applicants face while collecting diffraction data and while solving and refining novel structures. Applicants with crystals for data collection or with already collected data will be given strong consideration, although these are not mandatory requirements.
Several of the leading PX software developers from around the world will present lectures and tutorials on their software and will also be available to help with problems during hands-on sessions of the school.
Â
Practical X-ray course on methods in protein crystallography: data collection, data processing, and phasing
| - |
In Oulu
The course will be organised by Lari Lehtiö, Kristian Koski, Tiila Kiema, Ari-Pekka Kvist and Rik WierengaÂ
The course is supported by Biostruct-X, Biocenter Oulu, and the University of Oulu
There will be an international X-ray course at the Faculty of Biochemistry and Molecular Medicine of the University of Oulu, Oulu, Finland. The course will focus on data collection and data processing using iMOSFLM and XDS, to be complemented by lectures and tutorials on experimental phasing (SHELX) and molecular replacement phasing (CCP4). In addition there will be lectures on new techniques (XFEL diffraction and neutron crystallography). On the last day of the course there will be a remote data collection demonstration at Diamond Light Source, Oxford. The outline of the course follows the previous format, aiming for approximately 16-20 students, who will be provided with a computer in our linux class room. Data collection from own crystals will be possible using our in-house Bruker microfocus X-ray generator or remotely at Diamond.
Current approximate outline:
Monday, May 18:
Basic concepts of biomolecular crystallography, by Bernhard Rupp (USA)
Emerging techniques: XFEL by Janos Hajdu (Uppsala, Sweden): “The basic principles of the XFEL technology and molecular imaging"
Tuesday, May 19/Wednesday, May 20 (data processing):
XDS, Manfred Weiss, BESSY, Berlin, Germany (also XDSapp as available at Bessy)
iMOSFLM, Harry Powell (LMB, Cambridge, UK) Â (also data processing pipelines at Diamond)
Tuesday afternoon lecture by Bernhard Rupp on ligand binding studies
Wednesday, May 20/Thursday, May 21: (experimental and molecular replacement phasing)
Experimental phasing by SHELX, Thomas Schneider (EMBL, Hamburg)
Molecular replacement phasing by CCP4, Andrey Lebedev (CCP4, STFC)
Wednesday afternoon lecture on neutron crystallography by Dr. Zoe Fisher (ESS, Lund)
Thursday afternoon lecture by Thomas Schneider on the X-ray beamlines at EMBL, Hamburg
Â
Friday, May 22:
Remote data collection at Diamond (Martin Walsh, Diamond)
Crystal sample management and data tracking from crystal to PDB by xtalPiMS (Ed Daniel, Oulu)
Â
Throughout the course students will have time to work on their own topics in the linux class room and we will also provide the opportunity to collect data with our own equipment. Crystals that should be used for data collection in house or at Diamond should be available for freezing on the first day of the course or should be sent in advance to Oulu.
There will be a registration fee of 350Euro to cover the costs of accommodation and meals. We will try to make available fellowships to cover these costs. When applying to attend this course follow the instructions attached below.  Please provide information on crystals and/or datasets that you would like to send in advance. Indicate also if such a fellowship is needed when being accepted for this course. In case of oversubscription, students with own crystals and / or own data sets will be prioritised.
Please apply by by 10.01.2015
Â
RapiData 2015. Data Collection & Structure Solving. A Practical Course in Macromolecular X-ray Diffraction Measurement
| - |
In SSRL, Stanford, CA
