The Technion Center for Structural Biology (TCSB) is organizing a three day workshop on macromolecular crystallography under the auspices of the BioStruct-X project.

The workshop will include comprehensive theoretical lectures on all facets of crystallographic structure determination and hands-on tutorials. The lectures will be open to all, but the tutorials will be limited to 20 participants that will be chosen by committee. Lectures and tutorials will be given by Tom Terwilliger (Los Alamos), Randy Read (Cambridge), Zbigniew Dauter (Argonne), Karine Sparta (from the XDS development group) and members of the TCSB. The cost of participation in the full program is 200 Euro. More information, including fellowships, and the registration page can be found: http://tcsb-biox-wksp.net.technion.ac.il.

Â

The symposium runs from 2pm on Monday 11 until 3pm on Tuesday 12th April 2016.

 In April 2016 researchers, at all career stages, from across the globe will meet together to discuss recent innovations in the field of structural molecular biology.

This unique event being held at The University of Leeds, UK, has already attracted leading figures in this field including Professor Michael Levitt, FRS who was awarded the 2013 Nobel Prize in Chemistry for developing computational tools to dissect chemical reactions.


Other confirmed speakers:

• David Barford FRS (LMB, Cambridge)
• Martin Blackledge (IBS, Grenoble)
• Tim Clausen (IMP, Vienna)
• Sarah Harris (Astbury Centre, Leeds)
• Lewis E. Kay FRS (Toronto)
• Sheena Radford FRS, (Astbury Centre, Leeds)
• Helen Saibil FRS (Birkbeck)
• David Stuart FRS (Oxford)

Additional talks will be selected from abstracts submitted online, along with poster sessions. The symposium will be followed by a public engagement event and a public lecture by Professor Michael Levitt.

New Horizons and emerging biomedical challenges for Biophysics

Standard Registration closes: 1st April 2016 and Abstract submission for contributed talks: 15th March 2016. To register click here.

SCIENTIFIC PROGRAMME

There will be dedicated sessions covering cutting edge biophysical approaches to areas of major interest to the wider community. Opportunities are available to secure a platform presentation under the following themes:

• Cryo electron microscopy and X-ray lasers
• NMR of proteins and cells
• Channels and transporters
• Molecular recognition
• Neurodegeneration and ageing
• Advances in computational biophysics
• Single cell biophysics
• Proteins and complexes in human diseases
• Metals in biology
• Synthetic biology: enzymes & organisms
• Biological soft matter including stem cells
• Catalysis
• Drug discovery
• Membrane proteins and complexes

Confirmed speakers include: Sir David Baulcombe, Sir Tom Blundell, Richard Henderson, Dame Pamela Shaw, Sir Munir Pirmohamed, Greg Petsko, Sheena Radford FRS, James Naismith, FRS, Chris Schofield, FRS, Lucia Banci, Ben Bax, Paul O'Neil, Imre Berger, Sriram Subramanian, Richard Strange, Mike White, Liz Carpenter, Yvonne Jones, Masaki Yamamoto, Malcolm Jackson, Richard Garratt, José M Mato, Nigel Scrutton, Robert Eady, Nigel Robinson, Rasmita Raval, Mike Hough, Stefan Marklund, Nigel Minton, Paul Huang, Stefan Przyborski, Violaine See.

The workshop is part of the series of foresight workshops organized by the HZB.
The central theme of the workshop is the use of tender X-rays in the field of
macromolecular crystallography (MX). While typical MX experiments are conducted
at wavelengths of around 1.0 Ã... (energy 12.4 keV), there is an ever growing tendency
to also consider wavelengths in the tender X-ray region (1.5 â€" 3.0 A and beyond) for
MX applications. Examples are the possibility to determine the structures of native
proteins by sulphur anomalous scattering (native SAD), the unambiguous discrimination
from protein-bound solvent ions from water molecules, the determination of oxidation
states of relevant metal ions in protein structures, the investigation of solvent and
substrate channels using Xenon mapping, etc. In the workshop, some of these
modern developments will be highlighted and a case will be made for the increased
use of tender X-rays for MX applications.

Invited speakers include Wayne Hendrickson, James Holton, Armin Wagner, Leo
Chavas, Meitian Wang, Oliver Einsle, Markus Wahl and Oliver Daumke.

Registration is free of charge but limited to 100 participants. 4 Travel grants to attend
the workshop are generously offered by the company DECTRIS.

Â

Professor Dame Carol V. Robinson, FRS of the University of Oxford
Professor Janos Hajdu, Uppsala University

Topics

Plenary Lectures

Microsymposia

MS3. From Nature to Advanced Materials: Structure Characterization at the Nanoscale

MS4. New Topics in Crystal Growth Research

MS5. Nanostructures and Nanoscale Phenomena

MS6. Crystal Chemistry of Inorganic Compounds for the Understanding of Their Properties and Stability

MS7. Imaging Biomolecular Machines in Action through Cryo-Electron Diffraction and Cryo-Electron Microscopy

Focus Area Contacts

Focus Area 1: Michael Hennig, Basel for SIG 1:

Focus Area 2: Jürg Schefer, Paul Scherrer Institute Villigen, for SIG 5, 11, 12

Focus Area 3: Piero Macchi, Berne, for SIG 2, SIG 3, SIG 4

Focus Area 4: Katharina Fromm, Fribourg, for SIG 7 and SIG 13

Focus Area 5: Radovan Cerny, Geneva, for SIG 6, SIG 8 and SIG 9

Second joint Diamond-CCP4 MX workshop for graduate students, postdocs and early career scientists.

All aspects of structure solution will be covered during the workshop, from data collection through to phasing, refinement and validation.

• Lectures and tutorials will be delivered by experts in the field
• Two days of data collection time will be provided at Diamond's excellent MX beamlines
• You will be able to work alongside world-leading scientists and methods developers on your own projects
• All costs apart from travel will be covered

MXIS training course is dedicated to in situ protein crystallography. This 3-day workshop will include full lectures at the IBS and practical sessions at the ESRF, on beamlines FIP-BM30A and BM14. Full classes will be done in day 1 while practical sessions will be organized in subgroups that will be rotating from day 2 to day 3 (topics: ligand coating, crystallogenesis, in situ diffraction for crystal screening and structure resolution, in situ data processing). Possibility will be given to participants to practice on their own samples.

XXIII Users' Meeting.

 The ultimate aspiration of biology is to provide a comprehensive picture, over time and space, of the myriad of relationships between molecular structure, function and organization within bio-systems with increasing complexity level, ranging from single molecules to cells. Towards this aim, integrative approaches, which exploit state-of-the-art nano and sub-nano scale spatial resolution and unprecedented chemical sensitivity and selectivity, are required. The goal of this thematic workshop is to bring together biophysicists and biologists with scientists involved in the development of cutting-edge synchrotron-based and state-of-the art benchtop microscopies. The need for integrating the cluster of multidisciplinary synchrotron radiation based techniques with the newest laboratory approaches will be emphasized, focusing on their synergic interplay in the context of life-science.

Membrane Protein Expression/Purification

Free electron laser crystallography

Electron Microscopy

Simulations and ion channel function

Ion Channels

GPCRs

Pumps and ATPases

ABC Transporters