This RCSB Protein Data Bank (PDB) virtual course will be broadcast on 
Zoom. Please fill out the registration form to receive the Zoom link. 
Registration will be available online from March 1, 2023 to May 3, 2023.
 

LEARNING OBJECTIVES

Understand the basics of PDBx/mmCIF data dictionary and file format that 
underpin archiving of more than 200,000 experimentally determined 
three-dimensional biostructures in the PDB. Learn about software tools 
for generating and working with PDBx/mmCIF files, and programmatic 
access for harvesting PDB data. Main topics:

 * PDBx/mmCIF format description and examples
 * PDBx/mmCIF data model
 * Software tools for generating, editing, and visualizing PDBx/mmCIF 
files
 * PDBx/mmCIF dictionary extensions, including ModelCIF for computed
 structure models (CSM) from AI/ML
 * Parsing data from PDBx/mmCIF files for your research

WHO SHOULD ATTEND

Professionals and graduate students interested in learning about 
strategies to take full advantage of PDB data in the fields of:

 * Structural biology
 * Cheminformatics and computational chemistry
 * Bioinformatics and computational biology

 

Use PDB data to their full extent: Understanding PDBx/mmCIF

Wednesday, May 3rd 2023 | 1:00 PM EDT

Time: Thursday, February 23, 2023 at 9 AM pacific / 12 PM eastern time
Speaker: Radhika Malik, PhD, Research Assistant Professor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
 Hosted jointly by NCCAT, PNCC, & S2C2

Unconventional Experiments and Analysis Methods Enabled by Brighter X-Ray Sources

Lecture 21: Saulius Gražulius: "Open databases: what do we have, where are we going?"

Lecture 22: Julian Henn: "Global data quality metrics and data quality filter systems"

NIH sponsored Joint CryoEM Service Centers Webinar Series
Speaker: Â Dr Hanbin Jeong
Jan 26, 2023 12:00 PM in Eastern Time (US and Canada)Â 
 

Free CryoEM Webinar

The COVID-19 pandemic showed how poorly prepared we were to deal with a newly emerging respiratory virus. Antiviral drugs with the appropriate spectrum of activity can protect against a new pandemic threat until a vaccine can be developed and deployed. Drugs should be suitable for post-exposure prophylaxis or treatment of mild disease, possess oral activity with a good safety profile, have low cost of goods, and be easy to deliver and suitable for combination. The global research community must act collectively to generate a toolkit of antiviral agents covering a number of viral families. Scientists from many sectors â€" industry, academia, non-profits â€" will be involved, working in a multidisciplinary effort. This presentation provides a perspective on pandemic preparedness, the approaches that are being taken to tackle this problem, and the need to ensure equitable access to any drugs that are developed.

Monday, December 5, 2022, 8:00-9:30 AM (PST).
 

Speakers:

Prof. Peijun Zhang: Interrogating Human Viruses on a New Level
 

Dr. Thomas F. Kelly: Progress Toward Atomic-Scale Analytical Tomography

Advances in 3DEM to Address Complex Biological Questions

Utilising novel sample preparation techniques to enhance Cryo-EM structural analysis
12 noon ET/4pm GMT

SPT Labtech are proud to support a Drug Discovery World webinar with presentations from two researchers for whom new sample prep methods have been important factors in overcoming sample-specific challenges they encountered during structural analysis.

Prof Wei-Jen Tang, University of Chicago will speak about overcoming denaturation effects to determine cryo-EM structures of multiple states of the small human protein PreP at near atomic resolution.

Dr Radhika Malik, Icahn School of Medicine at Mont Sinai will discuss how overcoming strong preferred orientation issues resulted in the first structure of DNA Pol-zeta both without DNA and in the act of DNA synthesis.
Attendance at this webinar is free of charge, but registration is required

Lecture 14:Â Parthapratim Munshi:Â "On the Potency of Polymorphic Bioactive Molecules: A Quantum Crystallographic Perspective"

Lecture 15:Â Marcus A. Neumann:Â "Detecting and avoiding disappearing polymorph cases by crystal structure prediction"

 

Monday, October 10, 2022, 8:00-9:30 AM (PDT)

 
Prof. Peter J. Peters

Talk Title: Understanding the Invisible Hands of Sample Preparation for Cryo-EM
and 

Dr. Colin Ophus

 

Talk Title: Using Extremely Large 4D-STEM Experiments to Measure Materials Properties and Solve 3D Structures at Atomic Resolution

 

From the SLAC National Accelerator Lab with Prof. Tsumoru Shintake (OIST)

When: Friday, September 23, 2022 2:00 PM-3:00 PM (UTC-08:00) Pacific Time (US & Canada).

Program Description:
By blocking the central part of the objective lens in optical microscopy, we may improve resolution and contrast dramatically. This is a new type of telecentric optics based on central obscuration. This idea is a revival of old precession method in X-ray crystallography, which was developed by Martin J. Buerger at the beginning of the 1940's as a very clever alternative to collect Bragg diffractions without distorting the geometry of the reciprocal planes. In the EUV lithography, by introducing (precession method) rotating mirror and center obscured hollow mirror, we may go beyond 10 nm rule. In Cryo-EM, by precessing electron beam, we may directly observe molecule array in protein crystals, which provide powerful tool for protein analysis and drug discovery.

 

Please note that ONLY those with SUNet ID will have access to the recording of the seminar.

https://stanford.zoom.us/j/95714511566?pwd=QllFSjYzc3dXS3FBNkZYL294TXF2UT09#successhttps://stanford.zoom.us

 Meeting ID: 957 1451 1566

 Password: 284313

Fri, Jul 29 12:00-1:00pm central time | 
Presenter: Yimo Han, Rice University "Advancing Transmission Electron Microscopy for Materials Science and Biology"
 
 
 

Time: Thursday, June 30, 2022 at 9 AM pacific / 12 PM eastern time

Speaker: Francesca Vallese PhD, Associate Research Scientist, Columbia University Irving Medical Center

Title: Architecture of the human erythrocyte ankyrin-1 complex