The Next Generation of Nanotechnology: Materials, Applications, and Implications

Rational Design of Multi-Scale Materials and Their Emerging Applications

Intracellular Calcium Signals: Generation, Function and Therapeutic Intervention

The scientific programme will start on Thursday, June 15th and will finish on Saturday, June 17th.

There is no registration fee and we hope to meet you all in the beautiful city of Ljubljana.
Please register as soon as possible (no later than May 15th) using the Registration form
by sending it to slocro25@fkkt.uni-lj.si.
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We also expect your abstracts not later May 15th. Please use the template and send it to the e-mail address, given above.
The late or incomplete applications will not be taken into account.
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During the meeting, the Olex2 workshop will be organized for a limited number of participants. The workshop's participants will be selected by taking into account the arrival dates of their applications.
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Because the faculty is not very close to the city center where most hotels are located and also due to the tight schedule of the meeting, we suggest the participants to have lunch at the faculty restaurant (reduced price is offered to the SCCM25 participants. The Saturday lunch will be paid by the organizers. So please let us know if you are interested in having a free lunch.
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During the meeting (on Friday afternoon), the conference trip to explore Ljubljana and the conference dinner will also be organized.
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Participants are expected to arrange the accommodation by themselves.

The aim of this cross-disciplinary meeting will be to review and discuss the state-of-the-art in neutron diffraction at the nanoscale and to bring together researchers from a variety of scientific disciplines including soft matter, materials science, and biology. Current and future developments in the field, covering in real space up to a few tens of nm will be presented to promote and adapt the use of neutrons to the needs of the community.

Session I â€" Overview and principles

An overview of cryoEM: Richard Henderson (LMB-MRC, Cambridge, UK)

A Bayesian view on cryo-EM structure determination: Sjors Scheres (LMB-MRC, Cambridge, UK)

From hybrid methods to direct structure solving by cryoEM: a Spanish perspective: Jose López Carrascosa (CNB-CSIC, Madrid)

How to overcome biochemical limitations in sample preparation for high-resolution structure determination of macromolecular complexes by cryo-EM and X-ray crystallography: Holger Stark (MPIBPC, Göttingen, Germany)

Session II â€" Solution and reconstruction

EM reconstruction from the standpoint of Maximum Entropy estimation: Jorge Navaza (CNRS Emeritus at the École Normale Supériere de Cachan)

Solving X-ray crystal structures with cryo-EM reconstructions: Randy Read (CIMR, University of Cambridge, UK)

Repurposing molecular replacement algorithms for docking models in Cryo-EM reconstructions: Airlie McCoy (CIMR, University of Cambridge, UK)

Model-building in Low Resolution and Cryo-EM maps using Coot: Paul Emsley

Session III â€" Model Building to automation

Automated model building in cryoEM maps: Jon Agirre (YSBL, University of York, UK)

New approaches to the analysis of cryoEM maps quality:José María Carazo (CNB-CSIC, Madrid)

Structural studies of heterogeneous assemblies: Elena Orlova

Model-building using cryo-EM and crystallographic maps: Tom Terwilliger (Los Alamos National Laboratory, USA

Session IV â€" Refinement and Global Initiatives

 Refinement of atomic models into cryo-EM maps using REFMAC5: Garib Murshudov (LMC-MRC, Cambridge, UK).

New real space refinement methods for cryo-EM: Pavel Afonine (Lawrence Berkeley National Laboratory, Berkeley CA, USA)

The intersection of crystallography and cryo-EM in Phenix, new tools for both: Paul Adams (Lawrence Berkeley National Laboratory, Berkeley CA, USA)

Introducing the Collaborative Computational Project for Electron cryo-Microscopy: CCP-EM: Tom Burnley (CCPEM, UK)

Session V â€" Application and Future prospects

Investigating membrane protein structure and function by cryo-EM: Werner Kühlbrandt (Max-Plank Institut für Biophysik)

The emerging role of CryoEM in drug discovery and development: Paula da Fonseca (LMB-MRC, UK)

Cryo-EM at near-atomic resolution of icosahedral viruses: José Castón (CNB-CSIC, Madrid)

CryoEM illuminates the world of the Picornaviruses: Abhay Kotecha (Division of Structural biology, University of Oxford, UK)

Mechanistic insights on DNA replication and repair by cryo-EM: Rafael Fernandez Leiro (LMB-MRC, UK)

Structural studies of functional ribosome complexes: Paola Fucini (CIC-Biogune, Bilbao)

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The 6^th International caesar Conference presents leading research in molecular electron microscopy of dynamic biological entities.

The conference focuses on recent technological as well as methodological advances and their applications to fundamental biological questions.

Prior to the conference, there is a workshop (Monday & Tuesday, Sept. 11-12) on molecular Cryo-EM. The workshop covers both tomographic as well as single-particle techniques and is free of charge for registered conference participants. It aims at graduate students and (junior) postdocs. The workshop is limited to 20 participants. To register for the workshop, send an email to em2017@caesar.de using the subject "Workshop Registration".

Topics

• Materials for catalysis, energy generation and storage
• Nano-medicines, diagnostics and biomaterials
• Functional and engineered interfaces, surfaces, films, membranes and composites
• Advanced polymers, surfactants, gels, biocolloids and soft matter systems
• New theory, novel phenomena and experimental techniques

Topics

• Coordination chemistry, bio-inorganic chemistry and medicinal applications
• Electrochemistry and battery applications
• Inorganic catalysis
• Computational modelling and bonding
• Materials synthesis and functionality
• Environment and sustainability
• New methods of characterizing materials and processes
• Inorganic chemistry in exotic places (arts, archaeology, etc)
• Chemical education and didactics
• Thin films

The conference will be dedicated to the 60th anniversary of the Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research. Â A special session of the conference will also be dedicated to correlation Fourier diffractometry, marking the 25th anniversary of the start of operation of the Fourier diffractometer at the IBR-2 pulsed neutron reactor.

Online registration and abstract submission must be completed before 30th June 2017.

Equilibrated and Non-Equilibrated Systems for Anomalous Structures and Properties

Workshops will be held on the topics of:

• Membrane proteins and the methods of studying their structure;
• The structure and functions of the cells transcription apparatus;
• Subnanometer-resolution virus structures;
• Molecular organization of cells and organelles;
• New methods of sample preparation and data processing in cryo-electron microscopy.

 Keynote lectures:

 Prof Wolfgang Baumeister (Max-Planck-Institut für Biochemie, Germany)

 Dr Alexander Sobolevsky (Columbia University, NY, USA)

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Lomonosov Moscow State University will issue invitations for Russian visas for those who need them.

A recreation program that will take place after the Conference, including a visit to the Kremlin and Red Square in Moscow.